Accuracy of an integrated approach including clinical, analytical and imaging parameters for prognostication in hospitalized patients with acute pulmonary embolism

Abstract Funding Acknowledgements Type of funding sources: None. Background Acute pulmonary thromboembolism (PE) is a life-threatening condition and an early diagnosis adequate therapy are critical. Mortality in PE still remains very high spite progress diagnostic tools. Several parameters for risk stratification have been reported with variable importance on clinical practice. Purpose To compare the performance different (clinical, analytical imaging parameters) predicting adverse in-hospital events acute PE. Methods We retrospectively assessed consecutive patients from single center registry who were hospitalized due to Four determined: Clinical echocardiographic (PESI class PESI-Echo score), (lactate troponin I admission values) anatomical (central or peripheral thrombi location) parameters. A composite outcome (including cardiogenic shock, respiratory failure, severe bleeding mortality) was determined. Discriminative power each parameter by receiver operating characteristic curve analysis. Results total 131 (mean age 67.6 ± 15.3 years-old, female 71%) included. Regarding baseline comorbidities, 63.4% had hypertension, 27.4% recent hospitalization major surgery 19.8% medical history active. Besides anticoagulation, 7 (5.3%) underwent fibrinolysis. Overall mortality 8.4% 3.8% event, failure shock. According PESI classification, 29.8% included V, 26.7% III 17.6% II. classification weak positive correlation (p<0.001; r=0.37), like score (p = 0.018; r=0.36). Attending events, 72.2% occurred V 0.020). Both I) determined at hospital good discriminative outcome. superior lactate (AUC 0.864, 95% CI 2.8 – 187; p <0.001) vs data 0.64, 0.12). Comparing all-four parameters, best 1.0, 0.008), followed 0.925) value 0.856). The cut-off 211. Conclusion These results highlight prognostic addition usual scores stratification. In our cohort patients, showed overall stratifying events. Its application practice as additional tool could be interest.